Cardiovascular Revascularization Medicine
Volume 6, Issue 1 , Pages 7-13 , January 2005

Intracoronary β-irradiation prevents excessive in-stent neointimal proliferation in de novo lesions of patients with high plasma ACE levels. The BetAce randomized trial

  • Flavio Ribichini

      Affiliations

    • Division of Cardiology, Università del Piemonte Orientale, Ospedale Maggiore della Carita', Novara, Italy
    • Corresponding Author InformationCorresponding author. Catheterization Laboratory, Division of Cardiology, Università del Piemonte Orientale, Ospedale Maggiore della Carita' Corso Mazzini, Novara 18 28100, Italy. Tel.: +39 0321 373 3675; fax: +39 0321 373 3407.
  • ,
  • Valeria Ferrero

      Affiliations

    • Division of Cardiology, Università del Piemonte Orientale, Ospedale Maggiore della Carita', Novara, Italy
  • ,
  • Marleen Piessens

      Affiliations

    • Division of Radiation Oncology, OLV Hospital, Aalst, Belgium
  • ,
  • Guy R. Heyndrickx

      Affiliations

    • Cardiovascular Center, OLV Hospital, Aalst, Belgium
  • ,
  • Bernard de Bruyne

      Affiliations

    • Cardiovascular Center, OLV Hospital, Aalst, Belgium
  • ,
  • Luc Verbeke

      Affiliations

    • Division of Radiation Oncology, OLV Hospital, Aalst, Belgium
  • ,
  • Giuseppe Matullo

      Affiliations

    • Department of Genetics, Biology and Biochemistry, University of Torino, Italy
  • ,
  • Martin Büchi

      Affiliations

    • InterCorNet and the Division of Cardiology, University of Zurich, Switzerland
  • ,
  • Alberto Piazza

      Affiliations

    • Department of Genetics, Biology and Biochemistry, University of Torino, Italy
  • ,
  • Simonetta Guarrera

      Affiliations

    • Department of Genetics, Biology and Biochemistry, University of Torino, Italy
  • ,
  • Thomas F. Lüscher

      Affiliations

    • Department of Cardiology, University of Zurich, Switzerland
  • ,
  • William Wijns

      Affiliations

    • Cardiovascular Center, OLV Hospital, Aalst, Belgium

Received 22 February 2005 ,Accepted 22 February 2005.

References 

  1. Serruys PW, vanHout B, Bonnier H, Legrand V, Garcia E, Macaya C, et al. Randomised comparison of implantation of heparin-coated stents with balloon angioplasty in selected patients with coronary artery disease (Benestent II). Lancet. 1998;352:673–681
  2. Morice MC, Serruys PW, Sousa JE, Fajadet J, Ban Hayashi E, Perin M, et al. A randomized comparison of a sirolimus-eluting stent with a standard stent for coronary revascularization. N Engl J Med. 2002;346:1773–1780
  3. Moses JW, Leon MB, Popma JJ, Fitzgerald PJ, Holmes DR, O'Shaughnessy C, et al. Sirolimus-eluting stents versus standard stents in patients with stenosis in native coronary arteries. N Engl J Med. 2003;349:1315–1323
  4. Schofer J, Schluter M, Gershilck AH, Wijns W, Garcia E, Schampaert E, et al. Sirolimus-eluting stents for the treatment of patients with long atherosclerotic lesions in small coronary arteries: a double-blind, randomised controlled trial (E-SIRIUS). Lancet. 2003;362:1093–1099
  5. Stone GW, Ellis SG, Cox DA, Hermiller J, O'Shaughnessy C, Mann JT, et al. A polymer-based, paclitaxel-eluting stent in patients with coronary artery disease. N Engl J Med. 2004;350:221–231
  6. Hoffmann R, Mintz GS, Dussaillant GR, Popma JJ, Pichard AD, Satler LF, et al. Patterns and mechanism of in-stent restenosis. A serial intravascular ultrasound study. Circulation. 1996;94:1247–1254
  7. Lemos PA, Mercado N, van Domburg RT, Kuntz RE, O'Neill WW, Serruys PW. Comparison of late luminal loss response pattern after sirolimus-eluting stent implantation or conventional stenting. Circulation. 2004;110:3199–3205
  8. Teirstein PS, Massullo V, Jani S, Popma JJ, Mintz GS, Russo RJ, et al. Catheter-based radiotherapy to inhibit restenosis after coronary stenting. N Engl J Med. 1997;336:1697–1703
  9. King SB, Williams DO, Chougule P, Klein JL, Waksman R, Hilstead R, et al. Endovascular beta-radiation to reduce restenosis after coronary balloon angioplasty: results of the Beta Energy Restenosis Trial (BERT). Circulation. 1998;97:2025–2030
  10. Raizner AE, Oesterle SN, Waksman R, Serruys PW, Colombo A, Lim YL, et al. Inhibition of restenosis with β-emitting radiotherapy. Report of the Proliferation Reduction with Vascular Energy Trial (PREVENT). Circulation. 2000;102:951–958
  11. Serruys PW, Sianos G, van der Giessen W, Bonnier HJ, Urban P, Wijns W, et al. Intracoronary beta-radiation to reduce restenosis after balloon angioplasty and stenting; the Beta Radiation In Europe (BRIE) Study. Eur Heart J. 2002;23:1351–1359
  12. Verin V, Popowski Y, de Bruyne B, Baumgart D, Sauerwein W, Lins M, et al. Endoluminal beta-radiation therapy for the prevention of coronary restenosis after balloon angioplasty. The Dose-Finding Study Group. N Engl J Med. 2001;344:243–249
  13. Williams DO. Intracoronary brachytherapy: past, present and future. Circulation. 2002;105:2699–2700
  14. Serruys PW, Wijns W, Sianos G, de Scheerder I, van den Heuvel PA, Rutsch W, et al. Direct stenting versus direct stenting followed by centered beta-radiation with intravascular ultrasound-guided dosimetry and long-term anti-platelet treatment (BRIDGE). J Am Coll Cardiol. 2004;44:528–537
  15. Sabate’ M, Pimentel G, Prieto C, Corral JM, Banuelos C, Angiolillo DJ, et al. Intracoronary brachytherapy after stenting de novo lesions in diabetic patients. J Am Coll Cardiol. 2004;44:520–527
  16. Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest. 1990;86:1343–1346
  17. Ribichini F, Steffenino G, Dellavalle A, Matullo G, Colajanni E, Camilla T, et al. Plasma activity and insertion/deletion polymorphism of angiotensin I-converting enzyme. A major risk factor and a marker of risk for coronary stent restenosis. Circulation. 1998;97:147–154
  18. Amant C, Bauters C, Bodart JC, Lablanche JM, Grollier G, Danchin N, et al. D allele of the angiotensin I-converting enzyme is a major risk factor for restenosis after coronary stenting. Circulation. 1997;96:56–60
  19. Meurice T, Bauters C, Hermant X, Codron V, VanBelle E, McFadden EP, et al. Effect of ACE inhibitors on angiographic restenosis after coronary stenting (PARIS): a randomised, double-blind, placebo-controlled trial. Lancet. 2001;357:1321–1324
  20. Ribichini F, Ferrero V, Matullo G, Feola M, Vado A, Camilla T, et al. Association study of the I/D polymorphism and plasma ACE as risk factors for stent restenosis. Clin Sci. 2004;107:381–389
  21. Ribichini F, Matullo G, Piazza A, Vado A, Uslenghi E. Relationship between plasma ACE activity and the proliferative healing process in coronary vessel injury after coronary stenting. Atherosclerosis. 2000;152:261–263
  22. Buchi M, Hess OM, Kirkeeide RL, Suter T, Muser M, Osenberg HP, et al. Validation of a new automatic system for biplane quantitative coronary arteriography. Int J Card Imaging. 1990;5:93–103
  23. Koch W, Kastrati A, Mehilli J, Bottiger C, von Beckerath N, Schomig A. Insertion/deletion polymorphism of the angiotensin I-converting enzyme gene is not associated with restenosis after coronary stent placement. Circulation. 2000;102:197–202
  24. Ribichini F, Wijns W, Ferrero V, Matullo G, Camilla T, Guarrera S, et al. Effect of angiotensin-converting enzyme inhibition and restenosis after coronary stenting. Am J Cardiol. 2003;91:154–158
  25. Diet P, Pratt RE, Berry GJ, Momose N, Gibbons GH, Dzau VJ. Increased accumulation of tissue ACE in human atherosclerotic coronary artery disease. Circulation. 1996;94:2756–2767
  26. Ohishi M, Ueda M, Rakugi H, Okamura A, Naruko T, Becker AE, et al. Upregulation of angiotensin-converting enzyme during the healing process after injury at the site of percutaneous transluminal coronary angioplasty in humans. Circulation. 1997;96:3328–3337
  27. Ribichini F, Pugno F, Ferrero V, Bussolati G, Di Mario C, Colombo A. Angiotensin-converting enzyme tissue activity in the diffuse in-stent restenotic plaque. Circulation. 2000;101:e33–e35
  28. Costa MA, Sabaté M, Van der Giessen WJ, Kay IP, Cervinka P, Ligthart JM, et al. Late coronary occlusion after intracoronary brachytherapy. Circulation. 1999;100:789–792
  29. Waksman R, Bhargava B, Mintz GS, Mehran R, Lansky AJ, Satler LF, et al. Late total occlusion after intracoronary brachytherapy for patients with in-stent restenosis. J Am Coll Cardiol. 2000;36:65–68
  30. Kim DK, Kim JW, Kim S, Gwon HC, Ryu JC, Huh JE, et al. Polymorphism of the angiotensin-converting enzyme gene is associated with circulating levels of plasminogen activator inhibitor-1. Arterioscler Thromb Vasc Biol. 1997;11:3242–3247
  31. Waksman R, Weinberg J. Coronary brachytherapy in the drug-eluting stent era. Don't bury it alive. Circulation. 2003;108:386–388
  32. Ferrero V, Ribichini F, Heyndrickx G, De Bruyne B, Piessens M, Carlier S, et al. Angiographic and three-dimensional intravascular ultrasound analysis of combined intracoronary beta radiation and self-expanding stent implantation in human coronary arteries. Am J Cardiol. 2004;94:1237–1242

PII: S1553-8389(05)00031-X

doi: 10.1016/j.carrev.2005.02.005

Cardiovascular Revascularization Medicine
Volume 6, Issue 1 , Pages 7-13 , January 2005