Cardiovascular Revascularization Medicine
Volume 6, Issue 1 , Pages 38-43, January 2005

Drug-eluting stents for the treatment of in-stent restenosis:

A clinical review

  • Bryan P.Y. Yan

      Affiliations

    • Department of Cardiology, Royal Melbourne Hospital, Melbourne, Australia
    • Department of Epidemiology and Preventive Medicine, NHMRC Centre of Clinical Research Excellence in Therapeutics, Monash University, Melbourne, Australia
    • ,
  • Andrew E. Ajani

      Affiliations

    • Department of Cardiology, Royal Melbourne Hospital, Melbourne, Australia
    • Department of Epidemiology and Preventive Medicine, NHMRC Centre of Clinical Research Excellence in Therapeutics, Monash University, Melbourne, Australia
    • Corresponding Author InformationCorresponding author. Department of Cardiology, Royal Melbourne Hospital, Grattan Street, Parkville 3050, Australia. Tel.: +61 3 934 27000; fax: +61 3 934 72808.
    • ,
  • Ron Waksman

      Affiliations

    • Department of Cardiology, Washington Hospital Center, Washington, DC, United States

Received 14 April 2005; accepted 18 April 2005.

Abstract 

Treatment of in-stent restenosis (ISR) remains problematic despite the widespread application of drug-eluting stents (DES). Challenging lesion cohorts such as diffuse ISR and restenosis after failed intracoronary radiation therapy (IRT) maybe best treated with DES. The overall benefit of DES appears inferior to their utility in treating de novo coronary lesions. Randomised trials comparing DES and IRT will soon be available to determine the optimal therapy for ISR. The challenge to treat ISR in the DES era is the next frontier of interventional cardiology.

Keywords: In-stent restenosis, Drug-eluting stents, Sirolimus, Paclitaxel, Intracoronary radiation therapy

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PII: S1553-8389(05)00034-5

doi:10.1016/j.carrev.2005.04.003

Cardiovascular Revascularization Medicine
Volume 6, Issue 1 , Pages 38-43, January 2005

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