We are pleased to present the second issue of Cardiovascular Revascularization Medicine under its new name. Our hope is that our readers will enjoy this new multidisciplinary format and embrace its more diverse scope.

There are three Clinical Original articles in this issue. The first was based on Vicario et al.'s preclinical studies with autologous unfractionated bone marrow via coronary sinus with transitory occlusion, a clinical study in patients with chronic refractory angina, designed with objectives to evaluate tolerance of the procedure, safety, and feasibility, with a 1-year follow-up. In our second submission, Rigatelli et al. sought to determine safety and usefulness of angiography of extra-cardiac arteries performed by trained invasive cardiologists during cardiac catheterization. The last of our Clinical Original articles came from Dilcher et al., in which they aimed to determine the safety and feasibility of intracoronary radiation therapy in humans utilizing tungsten (188W), a beta emitter.

Our first Biology Original article is a submission from Carter et al. in which serial analysis was conducted of vessel wall shear stress following placement of metal and sirolimus stents to determine the relationship between shear stress and neointima. Next, Segev et al. aimed to evaluate the efficacy and toxicity of a human-grade purified collagenase, suitable for clinical use, in facilitating guide-wire crossing in a rabbit model of femoral artery chronic total occlusion.

We have two Case Reports in this issue as well. Roy et al. report the successful treatment of a giant proximal left circumflex artery aneurysm with distal occlusion in a 76-year-old man using the Symbiot PTFE-covered self-expandable stent, whereas Lotun et al. present a case of in-stent restenosis in a patient with a femoral anterior tibial artery in situ saphenous vein bypass graft successfully treated with brachytherapy.

In their Clinical Review, Sanaei Ardekani et al. reviewed available contrast-induced nephropathy data. And our Image of the Issue presents a 43-year-old Caucasian male and avid runner who was referred for evaluation after an episode of exercise-induced syncope.

We hope you continue to submit results of late-breaking trials, reviews, letters to the editor, and more. Thanks to those for their past submissions, and of course, thanks to all for your support.