Cardiovascular Revascularization Medicine
Volume 7, Issue 2 , Pages 54-60 , April 2006

Insulin resistance in nondiabetic patients with acute myocardial infarction

  • Kazuaki Nishio

      Affiliations

    • The Third Department of Internal Medicine, School of Medicine, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8666, Japan
    • Corresponding Author InformationCorresponding author. Heights Matsugaoka 202, 4105 Katsuyama, Fijikawaguchiko-machi, Minamitsuru-gun, Yamanashi 401-0310, Japan. Tel.: +81 555 72 2764; fax: +81 555 72 2764.
  • ,
  • Meiei Shigemitsu

      Affiliations

    • The Third Department of Internal Medicine, School of Medicine, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8666, Japan
  • ,
  • Taro Kusuyama

      Affiliations

    • The Third Department of Internal Medicine, School of Medicine, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8666, Japan
  • ,
  • Tomoyasu Fukui

      Affiliations

    • The First Department of Internal Medicine, School of Medicine, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8666, Japan
  • ,
  • Kitaro Kawamura

      Affiliations

    • The Third Department of Internal Medicine, School of Medicine, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8666, Japan
  • ,
  • Seiji Itoh

      Affiliations

    • The Third Department of Internal Medicine, School of Medicine, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8666, Japan
  • ,
  • Noburu Konno

      Affiliations

    • The Third Department of Internal Medicine, School of Medicine, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8666, Japan
  • ,
  • Takashi Katagiri

      Affiliations

    • The Third Department of Internal Medicine, School of Medicine, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8666, Japan

Received 8 November 2005 ,Revised 5 December 2005 ,Accepted 5 December 2005.

References 

  1. Oswald G, Smith C, Betteridge J, Yudkin J. Determinants and importance of stress hyperglycemia in non-diabetic patients with myocardial infarction. BMJ. 1986;293:917–922
  2. O'Sullivan J, Conroy R, Robinson K, Hickey N, Mulcahy R. In-hospital prognosis of patients with fasting hyperglycemia after first myocardial infarction. Diabetes care. 1991;14:758–760
  3. Bellodi G, Manicardi V, Malvasi V, Veneri L, Bernini G, Bossini P, et al. Hyperglycemia and prognosis of acute myocardial infarction in patients without diabetes mellitus. Am J Cardiol. 1989;64:885–888
  4. Fava S, Aquilina O, Azzopardi J, Muscat H, Fenech F. The prognostic value of blood glucose in diabetic patients with acute myocardial infarction. Diabetic Med. 1996;13:80–83
  5. Stubbs PJ, Laycock J, Alaghband-Zadeh J, Carter G, Noble MI. Circulating stress hormone and insulin concentrations in acute coronary syndrome: identification of insulin resistance on admission. Clin Sci. 1999;96:589–595
  6. Despres JP, Lamarche B, Mauriege P, Cantin B, Dagenais GR, Moorjani S, et al. Hyperinsulinemia as an independent risk factor for ischemic heart disease. N Engl J Med. 1996;334:952–957
  7. Reaven GM. Banting Lecture 188: Role of insulin resistance in human disease. Diabetes. 1988;37:1595–1607
  8. DeFronzo RA, Ferrannini E. Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care. 1991;14:173–194
  9. Piatti PM, Mario CD, Monti LD, Fragasso G, Sgura F, Caumo A, et al. Association of insulin resistance, hyperleptinemia, and impaired nitric oxide release with in-stent restenosis in patients undergoing coronary stenting. Circulation. 2003;108:2074–2081
  10. Hedblad B, Nilsson P, Engström G, Berglund G, Janzon L. Insulin resistance in non-diabetic subjects is associated with increased incidence of myocardial infarction and death. Diabet Med. 2002;19:470–475
  11. Cohn JN, Levine TB, Olivari MT, Garberg V, Luna D, Francis GS, et al. Plasma norepinephrine as a guide to prognosis in patients with chronic heart failure. N Engl J Med. 1984;311:819–823
  12. Jewitt DE, Mercer CL, Reid D, Valori C, Thomas M, Shillingford JP. Free noradrenaline and adrenaline excretion in relation to the development of cardiac arrhythmia and heart-failure in patients with acute myocardial infarction. Lancet. 1969;i:635–641
  13. Klein DJ, Anderson Friedman L, Harlan WR, Barton BA, Schreiber GB, Cohen RM, et al. Obesity and the development of insulin resistance and impaired fasting glucose in Black and White adolescent girls. Diabetes Care. 2004;27:378–383
  14. Tenerz A, Norhammar A, Silveira A, Hamsten A, Nilsson G, Rydén L, et al. Diabetes, insulin resistance, and metabolic syndrome in patients with acute myocardial infarction without previously known diabetes. Diabetes Care. 2003;26:2770–2776
  15. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentration in man. Diabetologia. 1985;28:412–419
  16. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1978;18:499–502
  17. Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science. 1993;259:87–91
  18. Kern PA, Ranganathan S, Li C, Wood L, Ranganathan G. Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance. Am J Physiol Endocrinol Metab. 2001;280:E745–E751
  19. Yamauchi T, Kamon J, Waki H, Terauchi Y, Kubota N, Hara K, et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med. 2001;7:941–946
  20. Alberti KGMM, Zimmet P for the WHO consultation. Definition, diagnosis and classification of diabetes mellitus and its complications: Part 1. Diagnosis and classification of diabetes mellitus—provisional report of a WHO consultation. Diabetic Med. 1998;15:539–553
  21. Anon . Myocardial infarction redefined: a consensus document of the Joint European Society of Cardiology/American College of Cardiology Committee for the Redefinition of Myocardial Infarction. Eur Heart J. 2000;21:1502–1513
  22. Anon . Myocardial infarction redefined: a consensus document of the Joint European Society of Cardiology/American College of Cardiology Committee for the Redefinition of Myocardial Infarction. J Am Coll Cardiol. 2000;36:959–969
  23. Opie LH. Glucose and the metabolism of ischemic myocardial infarction. Lancet. 1995;345:1520–1521
  24. Christenson NJ, Videbak J. Plasma catecholamines and carbohydrate metabolism in patients with acute myocardial infarction. J Clin Invest. 1974;54:278–286
  25. Stubbs PJ, Laycock J, Alaghband-Zadeh J, Carter G, Noble MI. Circulating stress hormone and insulin concentrations in acute coronary syndromes: identification of insulin resistance on admission. Clin Sci. 1999;96:589–595
  26. Pavlou HN, Kliridis PA, Panagiotopoulos AA, Goritsas CP, Vassilakos PJ. Euthyroid sick syndrome in acute ischemic syndromes. Angiology. 2002;53:699–707
  27. Klein I. Thyroid hormone and the cardiovascular system. Am J Med. 1990;88:631–637
  28. Willerson JT, Hutcheson DR, Leshin SJ, Faloona GR, Unger RH. Serum glucagon and insulin levels and their relationship to blood glucose values in patients with acute myocardial infarction and acute coronary insufficiency. Am J Med. 1974;57:747–753
  29. Wallace AM, McMahon AD, Packard CJ, Kelly A, Shepherd J, Gaw A, et al. Plasma leptin and the risk of cardiovascular disease in the West of Scotland Coronary Prevention Study (WOSCOPS). Circulation. 2001;104:3052–3056
  30. Schäfer K, Halle M, Goeschen C, Dellas C, Pynn M, Loskutoff DJ, et al. Leptin promotes vascular remodeling and neointimal growth in mice. Arterioscler Thromb Vasc Biol. 2004;24:112–117
  31. Kolaczynski JW, Nyce MR, Considine RV, Boden G, Nolan JJ, Henry R, et al. Acute and chronic effects of insulin on leptin production in humans: studies in vivo and in vitro. Diabetes. 1996;45:699–701
  32. Wabitsch M, Jensen PB, Blum WF, Christoffersen CT, Englaro P, Heinze E, et al. Insulin and cortisol promote leptin production in cultured human fat cells. Diabetes. 1996;45:1435–1438
  33. Bradley SJ, Kingwell BA, McConell GK. Nitric oxide synthase inhibition reduced leg glucose uptake but not blood flow during dynamic exercise in humans. Diabetes. 1999;48:1815–1821
  34. Shiuchi T, Nakagami H, Iwai M, Takeda Y, Cui T, Chen R, et al. Involvement of bradykinin and nitric oxide in leptin-mediated glucose uptake in skeletal muscle. Endocrinology. 2001;142:608–612
  35. Lusis AJ. Atherosclerosis. Nature. 2000;407:233–241
  36. Piatti PM, Monti LD, Zavaroni I, Valsecchi G, VanPhan C, Costa S, et al. Alteration in nitric oxide/cyclic-GMP pathway in nondiabetic siblings of patients with Type 2 diabetes. J Clin Endocrinol Metab. 2000;85:2416–2420
  37. Zavaroni I, Piatti PM, Monti LD, Gasparini P, Barilli LA, Massironi P, et al. Plasma nitric oxide concentrations are elevated in insulin-resistance healthy subjects. Metabolism. 2000;49:959–961
  38. Balletshofer BM, Rittig K, Enderle MD, Volk A, Maerker E, Jacob S, et al. Endothelial dysfunction is detectable in young normotensive first-degree relatives of subjects with Type 2 diabetes in association with insulin resistance. Circulation. 2000;101:1780–1784
  39. Monti LD, Barlassina C, Citterio L, Galluccio E, Berzuini C, Setola E, et al. Endothelial nitric oxide synthase polymorphisms are associated with Type 2 diabetes and the insulin resistance syndrome. Diabetes. 2003;52:1270–1275
  40. Petersen KF, Dufour S, Befroy D, Garcia R, Shulman GI. Impaired mitochondrial activity in the insulin-resistant offspring of patients with Type 2 diabetes. N Engl J Med. 2004;350:664–671

PII: S1553-8389(05)00196-X

doi: 10.1016/j.carrev.2005.12.004

Cardiovascular Revascularization Medicine
Volume 7, Issue 2 , Pages 54-60 , April 2006