Cardiovascular Revascularization Medicine
Volume 7, Issue 4 , Pages 234-236, October 2006

Aldosterone antagonists: a new treatment option for patients with post-myocardial infarction heart failure

  • Andrew E. Ajani

      Affiliations

    • Department of Cardiology, Royal Melbourne Hospital, Melbourne, Australia
    • National Health Medical Research Council, Centre of Clinical Research Excellence in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia
    • Corresponding Author InformationCorresponding author. Department of Cardiology, Royal Melbourne Hospital, Grattan Street, Parkville, 3050, Australia. Tel.: +61 3 9347 0499; fax: +61 3 9347 6760.
    • ,
  • Thomas H. Marwick

      Affiliations

    • University of Queensland Department of Medicine, Princess Alexandra Hospital, Brisbane, Australia
    • ,
  • Henry Krum

      Affiliations

    • National Health Medical Research Council, Centre of Clinical Research Excellence in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia

Received 6 July 2006; accepted 6 July 2006.

Abstract 

Heart failure (HF) in association with acute myocardial infarction is an emerging clinical problem. The benefits of aldosterone blockade have now been extended, with the selective aldosterone antagonist eplerenone demonstrating reduced mortality compared to placebo, in patients with post-myocardial infarction HF. The evidence supporting this agent will be briefly reviewed, followed by a discussion on the clinical implications of aldosterone antagonists in this clinical setting.

Keywords: Aldosterone antagonists, Heart failure, Myocardial infarction

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PII: S1553-8389(06)00185-0

doi:10.1016/j.carrev.2006.07.002

Cardiovascular Revascularization Medicine
Volume 7, Issue 4 , Pages 234-236, October 2006

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