Cardiovascular Revascularization Medicine
Volume 8, Issue 2 , Pages 94-98 , April 2007

Mechanisms of late lumen loss after antiproliferative percutaneous coronary intervention using beta-irradiation in a porcine model of restenosis

  • Carolin Deiner

      Affiliations

    • Department of Cardiology, Charité–Campus Benjamin Franklin, Berlin, Germany
    • ,
  • Christoph Loddenkemper

      Affiliations

    • Department of Pathology, Charité–Campus Benjamin Franklin, Berlin, Germany
    • ,
  • Ursula Rauch

      Affiliations

    • Department of Cardiology, Charité–Campus Benjamin Franklin, Berlin, Germany
    • ,
  • Peter Rosenthal

      Affiliations

    • Department of Radiation Therapy and Oncology, Charité–Campus Benjamin Franklin, Berlin, Germany
    • ,
  • Matthias Pauschinger

      Affiliations

    • Department of Cardiology, Charité–Campus Benjamin Franklin, Berlin, Germany
    • ,
  • Peter L. Schwimmbeck

      Affiliations

    • Department of Cardiology, Klinikum Leverkusen, Leverkusen, Germany
    • ,
  • Heinz-Peter Schultheiss

      Affiliations

    • Department of Cardiology, Charité–Campus Benjamin Franklin, Berlin, Germany
    • ,
  • Klaus Pels

      Affiliations

    • Department of Cardiology, Charité–Campus Benjamin Franklin, Berlin, Germany
    • Corresponding Author InformationCorresponding author. Department of Cardiology, Charité–Campus Benjamin Franklin, Hindenburgdamm 30, Berlin 12200, Germany. Tel.: +49 30 8445 2068; fax: +49 30 8445 4648.

References 

  1. Leon MB, Teirstein PS, Moses JW, Tripuraneni P, Lansky AJ, Jani S, et al. Localized intracoronary gamma-radiation therapy to inhibit the recurrence of restenosis after stenting. N Engl J Med. 2001;344:250–256
  2. Waksman R, White RL, Chan RC, Bass BG, Geirlach L, Mintz GS, et al. Intracoronary gamma-radiation therapy after angioplasty inhibits recurrence in patients with in-stent restenosis. Circulation. 2000;101:2165–2171
  3. Popma JJ, Suntharalingam M, Lansky AJ, Heuser RR, Speiser B, Teirstein PS, et al. Randomized trial of 90Sr/90Y beta-radiation versus placebo control for treatment of in-stent restenosis. Circulation. 2002;106(9):1090–1096
  4. Ong AT, McFadden EP, Regar E, de Jaegere PP, van Domburg RT, Serruys PW. Late angiographic stent thrombosis (LAST) events with drug-eluting stents. J Am Coll Cardiol. 2005;45(12):2088–2092
  5. Bertrand OF, Mongrain R, Thorin E, Lehnert S. Effects of low-dose-rate beta-irradiation on vascular smooth muscle cells: comparison with high-dose-rate exposure. Cardiovasc Radiat Med. 1999;1:125–130
  6. Schwartz RS. Ionizing radiation and vasculature: hot times for hot arteries. Catheter Cardiovasc Interv. 2004;62(3):391–392
  7. Fareh J, Martel R, Kermani P, Leclerc G. Cellular effects of beta-particle delivery on vascular smooth muscle cells and endothelial cells: a dose–response study. Circulation. 1999;99:1477–1484
  8. Pels K, Deiner C, Coupland SE, Noutsias M, Sutter AP, Schultheiss HP, et al. Effect of adventitial VEGF(165) gene transfer on vascular thickening after coronary artery balloon injury. Cardiovasc Res. 2003;60(3):664–672
  9. Pels K, Labinaz M, Hoffert C, O'Brien ER. Adventitial angiogenesis early after coronary angioplasty: correlation with arterial remodeling. Arterioscler Thromb Vasc Biol. 1999;19(2):229–238
  10. Labinaz M, Pels K, Hoffert C, Aggarwal S, O'Brien ER. Time course and importance of neoadventitial formation in arterial remodeling following balloon angioplasty of porcine coronary arteries. Cardiovasc Res. 1999;41(1):255–266
  11. Wilcox JN, Waksman R, King SB, Scott NA. The role of the adventitia in the arterial response to angioplasty: the effect of intravascular radiation. Int J Radiat Oncol Biol Phys. 1996;36(4):789–796
  12. Zalewski A, Shi Y. Vascular myofibroblasts. Lessons from coronary repair and remodeling. Arterioscler Thromb Vasc Biol. 1997;17(3):417–422
  13. Kohchi K, Takebayashi S, Hiroki T, Nobuyoshi M. Significance of adventitial inflammation of the coronary artery in patients with unstable angina: results at autopsy. Circulation. 1985;71(4):709–716
  14. Coussement PK, De Leon H, Ueno T, Salame MY, King SB, Chronos NA, et al. Intracoronary beta-radiation exacerbates long-term neointima formation in balloon-injured pig coronary arteries. Circulation. 2001;104(20):2459–2464
  15. Kaluza GL, Raizner AE, Mazur W, Schulz DG, Buergler JM, Fajardo LF, et al. Long-term effects of intracoronary beta-radiation in balloon- and stent-injured porcine coronary arteries. Circulation. 2001;103(16):2108–2113

☆ This study was supported by the Deutsche Forschungsgemeinschaft (RA 799/3-1).

PII: S1553-8389(06)00238-7

doi: 10.1016/j.carrev.2006.10.004

Cardiovascular Revascularization Medicine
Volume 8, Issue 2 , Pages 94-98 , April 2007

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