Cardiovascular Revascularization Medicine
Volume 8, Issue 4 , Pages 251-258 , October 2007

Early vascular response to overlapped paclitaxel-eluting stents in swine coronary arteries

Received 8 May 2007 ,Revised 13 August 2007 ,Accepted 13 August 2007.

References 

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  2. Stone GW, Ellis SG, Cox DA, Hermiller J, O'Shaughnessy C, Mann JT, et al. A polymer-based, paclitaxel-eluting stent in patients with coronary artery disease. N Engl J Med. 2004;350(3):221–231
  3. Stone GW, Ellis SG, Cannon L, Mann JT, Greenberg JD, Spriggs D, et al. Comparison of a polymer-based paclitaxel-eluting stent with a bare metal stent in patients with complex coronary artery disease: a randomized controlled trial. JAMA. 2005;294(10):1215–1223
  4. Lowe HC, Schwartz RS, Mac Neill BD, Jang IK, Hayase M, Rogers C, et al. The porcine coronary model of in-stent restenosis: current status in the era of drug-eluting stents. Catheter Cardiovasc Interv. 2003;60(4):515–523
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  6. Carter AJ, Aggarwal M, Kopia GA, Tio F, Tsao PS, Kolata R, et al. Long-term effects of polymer-based, slow-release, sirolimus-eluting stents in a porcine coronary model. Cardiovasc Res. 2004;63(4):617–624
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  8. Heldman AW, Cheng L, Jenkins GM, Heller PF, Kim DW, Ware M, et al. Paclitaxel stent coating inhibits neointimal hyperplasia at 4 weeks in a porcine model of coronary restenosis. Circulation. 2001;103(18):2289–2295
  9. van der Giessen WJ, Lincoff AM, Schwartz RS, van Beusekom HM, Serruys PW, Holmes DR, et al. Marked inflammatory sequelae to implantation of biodegradable and nonbiodegradable polymers in porcine coronary arteries. Circulation. 1996;94(7):1690–1697
  10. Schwartz RS, Chronos NA, Virmani R. Preclinical restenosis models and drug-eluting stents: still important, still much to learn. J Am Coll Cardiol. 2004;44(7):1373–1385
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  12. Balakrishnan B, Tzafriri AR, Seifert P, Groothuis A, Rogers C, Edelman ER. Strut position, blood flow, and drug deposition: implications for single and overlapping drug-eluting stents. Circulation. 2005;111(22):2958–2965
  13. Finn AV, Kolodgie FD, Harnek J, Guerrero LJ, Acampado E, Tefera K, et al. Differential response of delayed healing and persistent inflammation at sites of overlapping sirolimus- or paclitaxel-eluting stents. Circulation. 2005;112(2):270–278

☆ This study was sponsored and supported by Boston Scientific Corporation.

☆☆ All authors are full-time employees of Boston Scientific Corporation.

PII: S1553-8389(07)00292-8

doi: 10.1016/j.carrev.2007.08.002

Cardiovascular Revascularization Medicine
Volume 8, Issue 4 , Pages 251-258 , October 2007

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