Cardiovascular Revascularization Medicine
Volume 10, Issue 1 , Pages 49-54, January 2009

Myocardium selective densitometric perfusion assessment after acute myocardial infarction☆

  • Tamás Ungi

      Affiliations

    • Department of Radiology, Medical Faculty, Albert Szent-Györgyi Clinical Centre, University of Szeged, Szeged, Hungary
    • ,
  • Imre Ungi

      Affiliations

    • Second Department of Medicine and Cardiology Centre, Medical Faculty, Albert Szent-Györgyi Clinical Centre, University of Szeged, Szeged, Hungary
    • ,
  • Zsuzsanna Jónás

      Affiliations

    • Second Department of Medicine and Cardiology Centre, Medical Faculty, Albert Szent-Györgyi Clinical Centre, University of Szeged, Szeged, Hungary
    • ,
  • Viktor Sasi

      Affiliations

    • Second Department of Medicine and Cardiology Centre, Medical Faculty, Albert Szent-Györgyi Clinical Centre, University of Szeged, Szeged, Hungary
    • ,
  • András Lassó

      Affiliations

    • General Electric Healthcare, Budaörs, Hungary
    • ,
  • Zsolt Zimmermann

      Affiliations

    • Second Department of Medicine and Cardiology Centre, Medical Faculty, Albert Szent-Györgyi Clinical Centre, University of Szeged, Szeged, Hungary
    • ,
  • Tamás Forster

      Affiliations

    • Second Department of Medicine and Cardiology Centre, Medical Faculty, Albert Szent-Györgyi Clinical Centre, University of Szeged, Szeged, Hungary
    • ,
  • András Palkó

      Affiliations

    • Department of Radiology, Medical Faculty, Albert Szent-Györgyi Clinical Centre, University of Szeged, Szeged, Hungary
    • ,
  • Attila Nemes

      Affiliations

    • Second Department of Medicine and Cardiology Centre, Medical Faculty, Albert Szent-Györgyi Clinical Centre, University of Szeged, Szeged, Hungary
    • Corresponding Author InformationCorresponding author. Medical Faculty, Second Department of Medicine and Cardiology Centre, University of Szeged, Korányi fasor 6, P.O. Box 427, H-6720 Szeged, Hungary. Tel.: +36 62 545220; fax: +36 62 544568.

Received 11 August 2008; received in revised form 14 October 2008; accepted 23 October 2008.

Abstract 

Background

Myocardial perfusion is an important prognostic factor after recanalisation in acute myocardial infarction patients. We present a computerized, densitometric measurement method to assess myocardial perfusion on phase-matched digitally subtracted coronary angiograms.

Methods and materials

Quantitative myocardial perfusion was assessed by the Gmax/Tmax parameter of the time–density curves (TDCs) in infarct-related myocardial regions on X-ray coronary angiograms. Arteries were masked out from regions of measurement. This novel method has been compared with enzymatic infarct size, ST-segment resolution, and ejection fraction after successful revascularization of 62 patients with acute myocardial infarction.

Results

Significant correlations were found between Gmax/Tmax and enzymatic infarct size (R=−0.445, P<.001), ST-segment resolution (R=0.364, P=.004), and ejection fraction (R=0.278, P=.029). Bland and Altman plot of Gmax/Tmax reveals good interobserver agreement.

Conclusions

Gmax/Tmax of the TDC measured in the infarct-related myocardial area is a reliable parameter to assess clinical indicators of myocardial reperfusion. Therefore, results suggest that it could be used to immediately assess the success of recanalisation at the tissue perfusion level during coronary intervention, and as an objective end point in clinical trials of new interventional devices and drugs.

Keywords: Acute myocardial infarction, Cineangiography, Myocardial viability

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

☆ This study was partially supported by the Regional Cooperative Research Center of Life and Material Sciences of the University of Szeged together with industrial partner General Electric Healthcare Hungary. Dr. Tamás Ungi holds a Ph.D. scholarship from the University of Szeged.

PII: S1553-8389(08)00291-1

doi:10.1016/j.carrev.2008.10.001

Cardiovascular Revascularization Medicine
Volume 10, Issue 1 , Pages 49-54, January 2009

Article Tools

* Image Usage & Resolution