Cardiovascular Revascularization Medicine
Volume 13, Issue 1 , Pages 11-19 , January 2012

The role of oxidized phospholipids, lipoprotein (a) and biomarkers of oxidized lipoproteins in chronically occluded coronary arteries in sudden cardiac death and following successful percutaneous revascularization

  • Paul Fefer

      Affiliations

    • Schulich Heart Center, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada M4N 3M5
    • Current address: Sheba Medical Center, Tel Aviv University, Tel Aviv.
    • ,
  • Sotirios Tsimikas

      Affiliations

    • Vascular Medicine Program, University of California, San Diego, USA
    • ,
  • Amit Segev

      Affiliations

    • St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada
    • Current address: Sheba Medical Center, Tel Aviv University, Tel Aviv.
    • ,
  • John Sparkes

      Affiliations

    • Schulich Heart Center, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada M4N 3M5
    • ,
  • Fumiyuki Otsuma

      Affiliations

    • CVPath Institute, Gaithersburg, MD, USA
    • ,
  • Frank Kolodgie

      Affiliations

    • CVPath Institute, Gaithersburg, MD, USA
    • ,
  • Renu Virmani

      Affiliations

    • CVPath Institute, Gaithersburg, MD, USA
    • ,
  • Joseph Juliano

      Affiliations

    • Vascular Medicine Program, University of California, San Diego, USA
    • ,
  • Thierry Charron

      Affiliations

    • St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada
    • Current address: Hôpital du Sacré-Coeur de Montréal, Montréal, Québec.
    • ,
  • Bradley H. Strauss

      Affiliations

    • Schulich Heart Center, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada M4N 3M5
    • Corresponding Author InformationCorresponding author. Schulich Heart Center, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada M4N 3M5. Tel.: +1 416 480 6066; fax: +1 416 480 4745.

Received 17 April 2011 ,Revised 5 August 2011 ,Accepted 15 August 2011.

  • Image Result

    Representative histopathologic images of chronic total occlusion in human coronary arteries. (A–D) Histologic sections of chronic total occlusion at the proximal site of right coronary artery from a 6

    Representative histopathologic images of chronic total occlusion in human coronary arteries. (A–D) Histologic sections of chronic total occlusion at the proximal site of right coronary artery from a 65-year-old woman who died after hip fracture surgery. (A) A low-power image (Movat pentachrome) showing totally occluded artery with organized and recanalized thrombus. (B) A high-power image (hematoxylin-eosin stain) showing neovascular channels. (C) Same section as (A) showing positive staining for oxidized phospholipid epitopes using antibody EO6 in particular around organized thrombus. (D) Same section as (A) showing positive staining for malondialdehyde-like epitopes using human antibody IK17 within the organized thrombus. (E–H) Histologic sections of chronic total occlusion at the proximal site of right coronary artery from a 49-year-old man who died suddenly. (E) A low-power image (Movat pentachrome) showing organized and recanalized thrombus with multiple neovascular channels. (F) A high-power image (hematoxylin-eosin stain) showing large and small neovascular channels within the organized thrombus. (G and H) Same sections as (E) showing positive staining for EO6 (G) and IK17 (H) epitopes within the organized thrombus.

  • Image Result
    Percent change in OxPL/apoB in CTO after angioplasty of CTO and non-CTO coronary vessels. Note early rise and fall in OxPL/apoB in non-CTO vessels compared with a gradual and persistent rise in CTO ve

    Percent change in OxPL/apoB in CTO after angioplasty of CTO and non-CTO coronary vessels. Note early rise and fall in OxPL/apoB in non-CTO vessels compared with a gradual and persistent rise in CTO vessels. P values are for comparison of CTO and non-CTO vessels at each time point.

  • Image Result
    Percent change in Lp(a) in CTO after angioplasty of CTO and non-CTO coronary vessels. Note early rise and fall in Lp(a) in non-CTO vessels compared with a very mild rise in CTO vessels. P values are f

    Percent change in Lp(a) in CTO after angioplasty of CTO and non-CTO coronary vessels. Note early rise and fall in Lp(a) in non-CTO vessels compared with a very mild rise in CTO vessels. P values are for comparison of CTO and non-CTO vessels at each time point.

  • Image Result
    Percent change in MDA-LDL IgG (A) and IgM (B) after angioplasty of CTO and non-CTO coronary vessels. No significant differences are noted between groups.

    Percent change in MDA-LDL IgG (A) and IgM (B) after angioplasty of CTO and non-CTO coronary vessels. No significant differences are noted between groups.

  • Image Result
    Percent change in IC IgG (A) and IgM (B) after angioplasty of CTO and non-CTO coronary vessels. Significant differences are noted for IC-IgG at one week post angioplasty and at all time points post an

    Percent change in IC IgG (A) and IgM (B) after angioplasty of CTO and non-CTO coronary vessels. Significant differences are noted for IC-IgG at one week post angioplasty and at all time points post angioplasty for IC-IgM.

  • Image Result
    Percent change in hsCRP after angioplasty of CTO and non-CTO coronary vessels. No differences are noted between groups at any time points.

    Percent change in hsCRP after angioplasty of CTO and non-CTO coronary vessels. No differences are noted between groups at any time points.

☆ Disclosure: Dr Tsimikas is named as co-inventor of patents and patent applications related to oxidation-specific antibodies, has equity interest in Atherotope, and is a consultant to Quest Diagnostics. The other authors declare no conflicts of interest.

PII: S1553-8389(11)00501-X

doi: 10.1016/j.carrev.2011.08.001

Cardiovascular Revascularization Medicine
Volume 13, Issue 1 , Pages 11-19 , January 2012

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